science · 27 February 1998 · 26 years ago
death
Died 27 Feb 1998 at age 92 (born 18 Apr 1905).
American pharmacologist was a medical research pioneer who was awarded a share of the Nobel Prize for Physiology or Medicine in 1988 (with Gertrude B. Elion and Sir James W. Black) for development of drugs for several major diseases. In the 1950s, he and colleague Elion developed thioguanine and 6-mercaptopurine, that treated leukemia, and in 1957, azathioprine, used in treating severe rheumatoid arthritis and other autoimmune disorders. Their drug allopurinol was effective treatment for gout. Other important drugs they developed include pyrimethamine, an antimalarial agent; trimethoprim, a treatment for urinary and respiratory tract infections; and acyclovir, the first effective treatment for viral herpes.
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