science · 02 February 1980 · 44 years ago
death
Died 2 Feb 1980 at age 68 (born 25 Jun 1911).
William Howard Stein was an American biochemist who (with Stanford Moore and Christian B. Anfinsen) was a cowinner of the Nobel Prize for Chemistry in 1972 for their studies of the pancreatic enzyme ribonuclease. Stein, with Moore, investigated the connection between its chemical structure and the catalytic activity of the active centre of the ribonuclease molecule. Between 1949 and 1963, they developed methods for the analysis of amino acids and peptides obtained from proteins, determined the structure of ribonuclease, and it catalyzes the digestion of food. By 1972, they had also worked out the complete sequence of deoxyribonuclease, a molecule twice as complex as ribonuclease.
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