science · 15 July 1921 · 103 years ago
birth
Born 15 Jul 1921; died 14 May 2006 at age 84.
Robert Bruce Merrifield was an American biochemist who received the 1984 Nobel Prize for Chemistry for his development of the solid phase peptide synthesis method to build up large organic molecules on a solid matrix. He first attached an amino acid to small plastic polymer spheres, then added other amino acids, one after another, until a polypeptide chain was built up. The chain was then released from the polymer. Chains of amino acids can thus be built in any predetermined order to synthesize a wide variety of proteins, hormones, and other organic molecules. Merrifield's work has encompassed the development of resins, protecting groups and chemical strategies, and the engineering which brought automation to peptide chemistry.
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